In mathematics, 4-manifold is a 4-dimensional topological manifold. A smooth 4-manifold is a 4-manifold with a smooth structure. In dimension four, in marked contrast with lower dimensions, topological and smooth manifolds are quite different. There exist some topological 4-manifolds which admit no smooth structure and even if there exists a smooth structure it need not be unique (i.e. there are smooth 4-manifolds which are homeomorphic but not diffeomorphic).
4-manifolds are of importance in physics because, in General Relativity, spacetime is modeled as a pseudo-Riemannian 4-manifold.
Read more about 4-manifold: Topological 4-manifolds, Smooth 4-manifolds, Special Phenomena in 4-dimensions, Failure of The Whitney Trick in Dimension 4
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