Use and Effects
When used as a drug in its purified form, 5-MeO-DMT is smoked, insufflated, or injected and is active at a dose of as little as 2 mg. 5-MeO-DMT is also active orally, when taken with a monoamine oxidase inhibitor, but according to numerous reports, the combination with MAOI is extremely unpleasant and has a strong body load. According to the researcher Jonathan Ott, 5-MeO-DMT is active orally with doses over 30 mg without aid of an MAOI.
The onset of effects occurs within seconds after smoking/injecting, or minutes after insufflating, and the experience is sometimes described as similar to a near-death experience. Peak effects last for approximately 5–10 minutes when smoked. When insufflated, the peak effects are considerably less intense, but last for 15–25 minutes on average.
Although similar in many respects to its close relatives DMT and bufotenin (5-OH-DMT), the effects are typically not as visual. Some users report experiencing no visual effects from it even at very high doses.
Some report the effects to be unpleasant causing nausea and the feeling of being "sat on by an elephant".
Erowid lists the following effects for smoked 5-MeO-DMT:
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