Acetylcholine - Drugs Acting On The Cholinergic System

Drugs Acting On The Cholinergic System

Blocking, hindering or mimicking the action of acetylcholine has many uses in medicine. Drugs acting on the acetylcholine system are either agonists to the receptors, stimulating the system, or antagonists, inhibiting it.

ACh and its receptors
Drug Nm Nn M1 M2 M3
ACh, Charbacol, AChEi (Physostigmine, Galantamine, Neostigmine, Pyridostigmine) + + + + +
Nicotine, Varenicline + +
Succinylcholine +/-
Atracurium, Vecuronium, Tubocurarine, Pancuronium -
Epibatidine, DMPP +
Trimethaphan, Mecamylamine, Bupropion, Dextromethorphan, Hexamethonium -
Muscarine, Methacholine, Oxotremorine, Bethanechol, Pilocarpine + + +
Atropine, Tolterodine, Oxybutynin - - -
Vedaclidine, Talsaclidine, Xanomeline, Ipatropium +
Pirenzepine, Telenzepine -
Methoctramin -
Darifenacin, 4-DAMP, Darifenacin, Solifenacin -

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