Science and Technology
- Affinity chromatography
- Affinity electrophoresis
- Affinity laws, in hydraulics, used to express the relationship between variables involved in fan or pump performance
- Affinity (mathematics), an affine transformation (which preserves collinearity)
- Affinity (pharmacology), in biochemistry, protein-ligand binding
- Affinity (sociology), shared interests and commitments between persons in groups, "willingness to associate"
- Affinity (taxonomy), mainly in natural history - resemblance suggesting a common descent or type
- Electron affinity
- Processor affinity, a computing term for the assignment of a task to a given core of a multicore CPU
- Chemical affinity, the willingness of two or more elements or compounds to form a chemical or attractive bond of some type
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