- Simeon Stylites, prominent figure in Christianity
- Saint Maron, prominent figure in Christianity
- Jacob of Edessa, Syriac writer and theologian, 7th century
- Buhturi, iconic Arab poet
- Sayf al-Dawla al-Hamdani, ruler of Hamadanid dynasty
- Paul of Aleppo, 17th century Archdeacon of Aleppo, traveler and chronicler
- Philipp Stamma, chess master and writer
- Rizqallah Hassun, Syrian-Armenian poet, founded the first private Arabic newspaper in 1855
- Francis, Abdallah and Maryana Marrash, prominent writers and poets
- Abd al-Rahman al-Kawakibi, thinker and religious reformer
- Mar'i Pasha al-Mallah, politician and governor general of the State of Aleppo
- Qustaki al-Himsi, influential Syrian writer and poet
- Zeki Pasha, military officer and Field Marshal of the Ottoman forces in the Balkans
- Jacobo Harrotian, Mexican General officer participated in the Mexican Revolution
- Sati' al-Husri, founder of Arab nationalism
- Subhi Barakat, politician, president of the State of Syria 1925–1926
- Saadallah al-Jabiri, prime minister (1947) and patriotic leader
- Husni al-Za'im, first Syrian military dictator following independence
- John George, dwarf actor appeared in silent American movies
- Sami al-Hinnawi, leader of the second military coup in 1949
- Gabriel Acacius Coussa, cardinal and expert in canon law
- Nazim al-Kudsi, former president of Syria
- Jean Carzou, French-Armenian painter
- Omar Abu-Riche, influential Syrian poet
- Antranig Dzarugian, Armenian novelist and poet
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- Wahbi al-Hariri, artist and architect
- Sabri Mdallal, (1918–2006) classical songs performer
- Amin al-Hafiz, former president of Syria
- Fateh Moudarres, renowned Syrian painter
- Hilarion Capucci, titular archbishop of Caesarea and militant
- Moustapha Akkad, film producer and director
- George Tutunjian, Armenian revolutionary songs performer
- Toros Raskelenian, Syrian-French prize-winning sculptor of Armenian origin
- Sabah Fakhri, iconic Arabic traditional songs performer
- Ali Sarmini, renowned Syrian painter
- Muhammad Naji al-Otari, prime minister of Syria between 2003–2011
- Levon Ter-Petrossian, president of the Republic of Armenia between 1991–1998
- Abed Azrie, composer and classical songs performer
- Abd al-Rahman Mowakket, prize winner contemporary sculptor
- Harut Sassounian, Armenian-American writer, publisher of The California Courier
- Muhammed Faris, first Syrian cosmonaut
- Karnig Sarkissian, Armenian revolutionary songs performer
- Paul Baghdadlian, Armenian singer
- Najdat Anzour, TV director of Circassian origins
- Vartan Oskanian, minister of foreign affairs of Armenia between 1998–2008
- Raghda, contemporary actress
- Bassam Kousa, prominent actor
- Avraam Russo, Russian pop singer of Syrian-Armenian origin
- Hala Gorani, news anchor of CNN International
- Mohammad Afash, Syrian footballer notable for playing in Europe
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