In 1940 Noyes published a science-fiction novel, The Last Man (US title: No Other Man), in which the human race is almost wiped out by a powerful death ray capable of killing everyone, friend or foe, unless they are in a steel chamber deep under the surface of the sea. The inventor's chief assistant unscrupulously sells the plans to the leading nations of the world, who declare they will use the ray only as a "last resort". When events spiral out of control, however, they all activate it, killing everyone living on the earth.
When the death ray strikes, a 29-year-old Englishman named Mark Adams is trapped in a sunken submarine. Managing to escape, he finds himself the only survivor in Britain. He travels to Paris in the hope of finding another survivor. There he discovers a clue which gives him hope. His search leads him to Italy, where he finally finds the other survivor, an American girl named Evelyn Hamilton. At the time when the death ray struck, she was in a diving bell deep below the surface of the Mediterranean, where, under the guidance of Mardok, an immensely wealthy magnate and scientific genius, she was engaged in photographing the floor of the sea. Her companion turns out to be the villain of the story. Knowing the power of the ray, for whose development he had been largely responsible, he had made sure that, at the time of its activation, he was safely out of its reach, along with an attractive young woman with whom he could later begin the repopulation of the planet. Evelyn, however, finds him repulsive, and the arrival of the upstanding, handsome young Englishman further upsets Mardok's plan. In the ensuing competition between the two men for the girl, Mark Adams' surname is a clear hint at which of the two is better fitted to be Adam to Evelyn's Eve. The two young people fall in love, but Mardok kidnaps Evelyn. After her escape and Mardok's death, the novel concludes with the young couple's discovery of some other survivors at Assisi.
For Charles Holland, reviewing the novel in the 1940s, Noyes' combination of "such elements of human interest as apologetics, art, travel and a captivating love story" mean that the reader of The Last Man is assured of both "an intellectual treat and real entertainment". Eric Atlas, writing in an early science fiction fanzine, found the novel, despite some flaws, "well worth the reading — perhaps twice". The philosophico-religious theme, he wrote, "detracts in no way from the forceful characterizations...of Mark and Evelyn". Besides, most of the novel is set "in Italy, where Noyes' descriptive powers as a poet come to the fore". The Last Man seems to be the novel which introduced the idea of a doomsday weapon. It is thought to have been among the influences on George Orwell's Nineteen Eighty-Four.
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