Computers
- Alice (computer chip), graphics engine chip in the Amiga computer in 1992
- Alice (software), an object-oriented programming language and IDE developed at Carnegie Mellon
- A.L.I.C.E., a chatterbot based on AIML
- Alice ML, a functional programming language designed by the Programming Systems Lab at Saarland University
- Alice mobile robot, the "sugarcube" micro-robot
- Alice, the brand name used by Telecom Italia for internet and telephone services in Italy and San Marino and previously in Germany, France and the Netherlands
- Matra Alice, an early home micro-computer marketed in France
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