Apophis (Greek Apophis, Apophis) may refer to:
- Apep, an Ancient Egyptian mythological demon, in Greek known as Apophis
- Apepi (pharaoh), a Hyksos pharaoh of Lower Egypt
- 99942 Apophis, a near-Earth asteroid
- Apophis (Stargate), a Stargate SG-1 character based on the Egyptian demon