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- Advanced supercritical coal, a type of fossil fuel power plant
- Ambulatory surgery center, a type of health care facility
- American Solar Challenge, a solar car race now known as the North American Solar Challenge
- The Anglo-Saxon Chronicle, a collection of annals relating to Anglo-Saxon England
- ASC (dinghy), a 16 foot sailing dinghy in use with the Sea Cadet Corps in the UK
- Ascending order, when sorting; see collation
- Asia-Pacific Song Contest, song contest based on the Eurovision Song Contest
- Asian Science Camp, an annual science forum for pre-collegiate and collegiate students of Asia.
- Ashchurch for Tewkesbury railway station, a railway station in England (abbreviated per the National Rail code)
- Altered state of consciousness
- ASC, a British Jazz Band
- Antwerps schermcentrum (Antwerp Fencing Center), an Antwerp based fencing club
- Autism Spectrum Condition
- After Sozin's Comet, dating used in Avatar: The Last Airbender universe
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