There are several notable people with the surname Bertuzzi:
- Irnerio Bertuzzi (1919–1962), Italian airplane pilot
- Todd Bertuzzi (born 1975), Canadian hockey player
- Gian Ortensio Bertuzzi, Italian Mannerist painter
- Maria Teresa Bertuzzi, Italian mayor of Coppara
- Nicola Bertuzzi, Italian Rococo painter