Entertainment
- The Big Game, now Mega Millions, a U.S. multi-jurisdictional lottery game
- Big Game (album), the third album by the heavy metal band White Lion
- Big Game TV, a live phone-in quiz channel
- The Big Game (film), a 1972 film directed by Robert Day
- The Big Game (game show), which aired only in 1958
- "The Big Game", an annual parody of the Super Bowl featured on Cartoon Network from 1998 through 2001
- PokerStars Big Game, a televised poker show which began airing in 2010
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