Buffy may refer to:
- Buffy the Vampire Slayer (disambiguation), various media on the TV series.
- The Buffy EP, 1999 EP by Velvet Chain
- Buffy coat, a component of blood
- Buffy (album), a 1974 album by Buffy Sainte-Marie for MCA Records
- 2004 XR190, trans-Neptunian object, tentatively nicknamed Buffy
Read more about Buffy: People