Callisto may refer to:
- Callisto (mythology), a nymph
- Callisto (moon), a moon of Jupiter
- Callisto (moth), a genus of moths in the Gracillariidae family
- Callisto (Xena), a character on Xena: Warrior Princess
- "Callisto" (Xena: Warrior Princess episode)
- Callisto (comics), a fictional mutant in X-Men
- Callisto series, a sequence of novels by Lin Carter
- Callisto (band), a band from Turku, Finland
- Callisto, a novel by Torsten Krol
- Callisto, a release of version 3.2 of Eclipse, an integrated development environment
- Callisto, an AMD Phenom II processor core