Cassette may refer to:
- In general, a small Cartridge. It may refer specifically to:
- Compact Cassette, a worldwide standard for analog audio recording and playback, also known as audio cassette, cassette tape, or tape
- Digital Audio Tape (or DAT), a digital audio cassette tape format, mainly used by professionals
- Digital Compact Cassette (or DCC), a short-lived digital audio cassette format aimed at domestic users
- Videocassette, a cassette containing videotape, for use in VCRs
- Data cassette, magnetic tape in plastic housing
- Album (Public Image Ltd album), a 1986 Public Image Ltd album called "Cassette" on certain editions
- Cassette, a set of multiple sprockets on a bicycle
- Cassette (New Zealand band), a band from New Zealand
- Cassette (South African band), a band from South Africa. They won the South African Music Award (SAMA) for best rock album 2007
- Gene cassette, certain vectors that are normally used to confer a selectable marker on an organism