Cinchona - History

History

South America

According to legend, the first European ever to be cured from malaria fever was the countess of Chinchón, the wife of the Spanish Luis Jerónimo de Cabrera, 4th Count of Chinchón - the Viceroy of Peru. The namesake Chinchón is a small town in central Spain. In the Viceroyalty of Peru, the court physician was summoned and urged to save the countess from the waves of fever and chill threatening her life, but every effort failed to relieve her. At last, the physician administered some medicine he had obtained from the local Indians, who had been using it for similar syndromes. The countess survived the malarial attack and reportedly brought the cinchona bark back with her when she returned to Europe in the 1640s.

Europe

The Italian botanist Pietro Castelli wrote a pamphlet noteworthy as being the first Italian publication to mention the cinchona. By the 1630s (or 1640s, depending on the reference), the bark was being exported to Europe. In the late 1640s, the method of use of the bark was noted in the Schedula Romana, and in 1677, the use of the bark was noted in the London Pharmacopoeia.

Charles II called upon Robert Talbor, who had become famous for his miraculous malaria cure. Because at that time the bark was in religious controversy, Talbor gave the king the bitter bark decoction in great secrecy. The treatment gave the king complete relief from the malaria fever. In return, he was offered membership of the prestigious Royal College of Physicians.

In 1679, Talbor was called by the King of France, Louis XIV, whose son was suffering from malaria fever. After a successful treatment, Talbor was rewarded by the king with 3,000 gold crowns and a lifetime pension for this prescription. Talbor, however, was asked to keep the entire episode secret.

After Talbor's death, the French king found this formula: six drams of rose leaves, two ounces of lemon juice and a strong decoction of the cinchona bark served with wine. Wine was used because some alkaloids of the cinchona bark are not soluble in water, but are soluble in the ethanol in wine.

In 1738, Sur l'arbre du quinquina, a paper written by Charles Marie de La Condamine, a member of the expedition that was sent to Peru to determine the length of a degree of the meridian arc in the neighbourhood of the equator, was published by the French Academy of Sciences. In it he identified three separate species.

In 1742, on the basis of a specimen received from La Condamine, Linnaeus named the tree Quinquina condaminiae and established a new genus, which he termed Cinchona quinquina condaminiae. In 1753, he described Cinchona officinalis as a separate species.

Homeopathy

The birth of homeopathy was based on cinchona bark testing. The founder of homeopathy, Samuel Hahnemann, when translating William Cullen's Materia medica, noticed Cullen had written that Peruvian bark was known to cure intermittent fevers. Hahnemann took daily a large, rather than homeopathic, dose of Peruvian bark. After two weeks, he said he felt malaria-like symptoms. This idea of "like cures like" was the starting point of his writings on homeopathy. Hahnemann's symptoms are believed to be the result of a hypersensitivity to cinchona bark on his part.