Cosimo may refer to:
Popes:
- Pope Innocent VII (c. 1336–1406), born Cosimo de' Migliorati
Members of the Medici family:
- Anna Maria Luisa de' Medici (1667-1743), daughter of Cosimo III de' Medici, Grand Duke of Tuscany
- Cosimo de' Medici (1389–1464), ruler of Florence, Italy
- Cosimo di Giovanni de' Medici (disambiguation), any of several people of the same name
- Cosimo I de' Medici, Grand Duke of Tuscany (1519–1574)
- Cosimo II de' Medici, Grand Duke of Tuscany (1590–1621)
- Cosimo III de' Medici, Grand Duke of Tuscany (1642–1723)
- Ferdinando (III) de' Medici (1663–1713), hereditary prince of Tuscany
- Gian Gastone de' Medici, Grand Duke of Tuscany (1671-1737)
- Giovanni de' Medici (1421-1463), Italian banker
- Giovanni de' Medici (cardinal) (1544-1562)
- Lorenzo de' Medici (1449-1492), Florentine statesman
- Lucrezia de' Medici (1544–1562), daughter of Cosimo I de' Medici, Grand Duke of Tuscany
- Maria de' Medici (1540-1557), daughter of Cosimo I de' Medici, Grand Duke of Tuscany
- Piero di Cosimo de' Medici (1416–1469), ruler of Florence
Articles related to the Medici family:
- Ancestors of Cosimo I de Medici in three generations
- Descendants of Cosimo I de Medici in three generations
- Portrait of a Man with a Medal of Cosimo the Elder, c. 1474-1475 painting by Sandro Botticelli
- Portrait of Cosimo I de' Medici, 1545 painting by Agnolo di Cosimo
- Statue of Cosimo I, 1596 statue in Pisa, Italy
People with the surname Cosimo:
- Bronzino (proper name Agnolo di Cosimo), (1503–1572), Florentine painter
- Piero di Cosimo (1462–1522), Italian painter
Works by Piero di Cosimo:
- Portrait of Simonetta Vespucci (Piero di Cosimo), c. 1480 painting by Piero di Cosimo
- The Myth of Prometheus (Piero di Cosimo), 1515 series of five panels by Piero di Cosimo
Real people with the given name Cosimo:
- Cosimo Antonelli (b. 1925), Italian water polo player
- Cosimo Bartoli (1503–1572), Italian diplomat and humanist
- Cosimo Boscaglia (c.1550–1621), Italian professor of philosophy
- Cosimo Caliandro (b. 1982), Italian middle distance runner
- Cosimo Cavallaro (b. 1961), Italian-Canadian artist
- Cosimo Commisso (soccer), Canadian soccer player
- Cosimo Daddi (before 1575-1630), Italian painter
- Cosimo Fancelli (c. 1620-1688), Italian sculptor
- Cosimo Fanzago (1591-1678), Italian architect and sculptor
- Cosimo Lotti (1571-1643), Italian engineer
- Cosimo Matassa (b. 1926), Italian-American studio owner
- Cosimo Morelli (1732-1812), Italian architect
- Cosimo Perrotta, Italian professor of economic history
- Cosimo Pinto (b. 1943), Italian boxer
- Cosimo Rosselli (1439-after 1506), Italian painter
- Cosimo Tura (c. 1430-1495), Italian painter
- Cosimo Ulivelli (1625-1704), Italian painter
Fictional people with the given name Cosimo:
- Cosimo Piovasco di Rondò, hero of Italo Calvino's 1957 novel The Baron in the Trees