CRB can mean:
- CRB Racing, an Australian International Pedal Prix Team in Australia
- Capitol Records Building, landmark office tower in Hollywood, Los Angeles, California
- Central Railway Building, in the Bangladesh
- Centre de Recherche Berbère
- Chairman Railway Board of the Indian Railways
- Clube de Regatas Brasil, a Brazilian football team
- Claremont Review of Books, a political journal
- Clinical Research Bureau, the first birth control clinic in the United States
- Contract Recognition Board, in motor racing
- Copyright Royalty Board
- Committee for Relief in Belgium
- Commodity Research Bureau, in economics
- Cramér–Rao bound, in statistics
- Criminal Records Bureau, in the United Kingdom
CrB can mean:
- Corona Borealis (constellation), standard astronomical abbreviation