Custis can refer to:
- Daniel Parke Custis, son of John Custis and first husband of Martha Dandridge Custis Washington
- Eleanor Parke Custis, adopted daughter of George Washington
- George Washington Parke Custis, son of John Parke Custis and adopted son of George Washington
- John Custis, member of the Virginia governor's Council and father of Daniel Parke Custis
- John Parke Custis, son of Daniel Parke Custis and stepson of George Washington
- Martha Dandridge Custis Washington, wife of George Washington
- Mary Anna Custis, daughter of George Washington Parke Custis and wife of General Robert E. Lee
- Mary Lee Fitzhugh Custis, wife of George Washington Parke Custis
- Custis Trail, a bicycle trail in Arlington, Virginia