Chronology
- 1550: Portuguese ships visit Hirado.
- 1561: Following the murder of foreigners in the area of the Hirado clan, Portuguese began to look for other ports to trade.
- 1570: Christian daimyo Ōmura Sumitada make a deal with the Portuguese to develop Nagasaki, six town blocks are built.
- 1571: Nagasaki Harbor is opened for trade, the first Portuguese ships enter.
- 1580: Omura Sumitada cedes jurisdiction over Nagasaki and Mogi to the Jesuits.
- 1588: Toyotomi Hideyoshi exerts direct control over Nagasaki, Mogi, and Urakami from the Jesuits.
- 1609: The Dutch East India Company opens a factory in Hirado. It closes in 1641 when it is moved to Deshima.
- 1612: Japan's feudal government decrees that Christian proselytizing on Bakufu lands is forbidden.
- 1616: All trade with foreigners except that with China is confined to Hirado and Nagasaki.
- 1634: The construction of Dejima begins.
- 1636: Dejima is completed; the Portuguese are interned on Dejima (Fourth National Isolation Edict).
- 1638: Shimabara Rebellion of Christian peasants is repressed with Dutch support, Christianity in Japan is repressed.
- 1639: Portuguese ships are prohibited from entering Japan. Consequently, the Portuguese are banished from Dejima.
- 1641: The Dutch East India Company Trading Post in Hirado is moved to Nagasaki.
- 1649: German surgeon Caspar Schamberger comes to Japan. Beginning of a lasting interest in Western style medicine.
- 1662: A shop is opened on Dejima to sell Imari porcelain.
- 1673: The English ship "Return" enters Nagasaki, but the Shogunate refuses its request for trade.
- 1678: A bridge connecting Dejima with the shore is replaced with a stone bridge.
- 1690: The German physician Engelbert Kaempfer comes to Dejima.
- 1696: Warehouses for secondary cargo reach completion on Dejima.
- 1698: The Nagasaki Kaisho (trade association) is founded.
- 1699: The Sea Gate is built at Dejima.
- 1707: Water pipes are installed on Dejima.
- 1775: Carl Thunberg starts his term as physician on Dejima.
- 1779: Surgeon Isaac Titsingh arrives for his first tour of duty as "Opperhoofd".
- 1798: Many buildings, including the Chief Factor's Residence, are destroyed by the Great Kansei Fire of Dejima.
- 1804: Russian Ambassador N.P. Rezanov visits Nagasaki to request an exchange of trade between Japan and Imperial Russia.
- 1808: The Phaeton Incident occurs.
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