Destra may refer to:
- Destra Garcia, singer and songwriter from Trinidad and Tobago in the Caribbean
- Destra Corporation, an Australian company
- La Destra ('The Right'), a conservative Italian political party
- Destra Liberale Italiana (DLI) 'Italian Liberal Right', a tiny Italian political party
- Tony Destra, (1954-1987) an American drummer
- Mano Destra, a 1986 lesbian art film
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