Pharmacology
- Noncompetitive N-methyl--aspartate receptor (NMDAR) antagonist.
- σ1 and σ2 sigma receptor agonist.
- α3β4, α4β2, and α7 nicotinic acetylcholine receptor antagonist.
- -Type voltage-gated calcium channel (LVGCC) blocker.
The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an NMDA receptor antagonist as well as essentially inactive as a serotonin reuptake inhibitor.
Read more about this topic: Dextrorphan
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