Entertainment
- Downstream (novella) by French writer Joris-Karl Huysmans
- Downstream (album), an album by New Monsoon
- "Downstream" (Land of the Lost), an episode of the 1974 series Land of the Lost
- Downstream (2010 film), a 2010 action science fiction film
- Downstream (1992 film), a 1992 crime film
- Downstream (song) the fourth song in the Supertramp Even in the Quietest Moments album
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