DTE may refer to:
- Data terminal equipment, an end instrument used in telecommunication and data transmission
- Distance to empty, a feature in an automobile electronic instrument cluster
- Dithioerythritol, a chemical
- DTE (direct to edit), a digital video recording method
- DTE80, the Microsoft Development Environment 8.0 Extensibility namespace
- DTE Energy, a Detroit, Michigan-based utility
- Dual-Tile encoding, another name for Byte pair encoding
- Desktop engineering, the process of engineering design using desktop computers
- Desktop Engineering Ltd, a UK based company involved in engineering software