EDN may refer to:
- Encyclopédie des Nuisances, a French magazine and publisher
- EDN (magazine), an engineering magazine, originally called Electrical Design News
- Endothelin, a chemical substance
- Eden Park railway station, a British Railway station with the station code EDN
- Earth Day Network, a coordinating body for Earth Day events
- Enterprise Municipal Airport (Alabama) (FAA LID: EDN)
- Equal Device Network, a device interconnection network
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