EDR may refer to:
- Election Day Registration, also known as "same-day voter registration"
- Event Data Recorder, a device installed in automobiles, trucks, planes, locomotives, or ships to record crash data
- EDR Desalination, an electrodialysis process
- European Drawer Rack, a part of the International Space Station
- European depository receipt
- Electrodermal response, a method of measuring the electrical resistance of the skin
- Emergency Detour Route, a pre-established detour system for major highways in Ontario
- Ems Dollart Region, an INTERREG-IV organisation on the Dutch/German Border
- Enhanced Data Rate, a feature of the Bluetooth protocol
- Equivalence of Direct Radiation, a standardized comparison method for space-heating radiators
- Experimenterende Danske Radioamatører, an amateur radio organization in Denmark
- Elio Di Rupo, the Prime Minister of Belgium since 6 December 2011
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