Epiphanes may refer to:
- Zeus, King of Greek Gods
- Epiphanes (gnostic), legendary Gnostic writer
- Ptolemy V Epiphanes (reigned 204–181 BC), ruler of the Ptolemaic dynasty
- Antiochus IV Epiphanes (c. 215–164 BC), ruler of the Hellenistic Seleucid Empire
- Gaius Julius Antiochus IV Epiphanes (aka Antiochus IV Epiphanes or Antiochus IV of Commagene), the last king of Commagene who reigned between 38-72.
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