ETR may refer to:
- Etravirine (Intelence/TMC125), an antiretroviral drug used in HAART to supress HIV replication
- East Turkestan Republic (disambiguation)
- ElettroTreno, a series of Italian high-speed trains
- Express Toll Route, in Canada
- Eastern Test Range, a rocket testing area off of Cape Canaveral
- Effective Tax Rate, a method of expressing the overall percentage of a company's revenue which is paid in taxes
- Entergy Corporation, NYSE stock symbol
- Essex Terminal Railway, a short line railroad in Canada
- Elstree Airfield, the IATA airport code
- Exponential trace function of linear algebra, usually written in lower case (etr)
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