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- International license plate code for Liechtenstein
- Fastest lap in motorsports
- Foreign language
- The Flaming Lips, an American rock band
- Freelancer, a self-employed professional
- fl., floruit (Latin, "flourished"), used to indicate periods when a person, organization, or species was influential
- fl (fl), a common typographical ligature
- Fluorouracil (5-FU) and leucovorin (folinic acid), a chemotherapy regimen for treating colon cancer
- Follicular lymphoma in medicine
- Fluffy transcription factor
- FLT3LG (Fms-related tyrosine kinase 3 ligand)
- Federal League, a US baseball league in 1914
- Floor, the floor number in a highrise structure also called storey
- Fl., the abbreviation of the Roman praenomen/gens Flavius
- Flagship Lounge, the first class lounge of American Airlines
- Flerovium, chemical element 114, not to be confused with fluorine (F)
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