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- 5-lipoxygenase activating protein (FLAP)
- brouhaha, a general state of social agitation
- flap (aircraft), a hinged surface on the trailing edge of an airplane wing
- flap (surgery), a surgical technique involving movement of vascularized tissue
- free flap, a specific kind of surgical flap
- flap consonant, a sound produced by brief contact between the tongue and the roof of the mouth
- intervocalic alveolar flapping, a process by which a /t/ or a /d/ before an unstressed vowel is flapped
- flap, any hinged plate often used as a cover or a simple one-way valve
- bum flap (or butt flap), a separately removable part of underwear (un)covering the buttocks
- cat flap or pet door, a hinged flap that allows a cat or other small pet to enter or leave a room or building
- sluice or flap gate, a pressure driven water flow control device between a channel and other water body
- flapping, one of the basic mechanics of flight in birds
- roof flap, an aerodynamic feature of race cars
- route flapping, when a router alternately advertises a destination network first via one route then another
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