FPE, a three letter acronym, can refer to:
- Far-point of accommodation
- Federal Pacific Electric, an electrical supply company noted for their faulty circuit breakers
- Federation of Public Employees, a union forming part of the American Federation of Teachers
- Format-Preserving Encryption, mode of operation of a block cipher that keeps the format of the encrypted data the same as the format of the unencrypted data
- Free People of Earth, a fictional government in Orson Scott Card's novel Shadow of the Giant
- FrontPage Extensions, website add-ons supported by Microsoft FrontPage
- Fuel Price Escalator, a tax rise mechanism during the 1990s in the United Kingdom
- Fire Protection Engineer, an occupation focusing on design of buildings, environments, and detection and suppression systems to minimize the chance and impact of fires
- Floating point exception, a type of exception in computer programming
- Final Pensionable Earnings, a component used to calculate the actual value of a pension under certain pension schemes.