GCF can refer to:
- Game Cache File, a filetype used by the Valve's Steam service
- Gauche Communiste de France (Left Communist of France), a French political party.
- Global Certification Forum
- Good Clean Fun, a hardcore punk band
- Google Chrome Frame
- Government Secure Intranet Convergence Framework, a UK government computer network
- Greatest common factor, an alternative term of the mathematical term greatest common divisor
- Green Climate Fund
- Guam Cycling Federation
- Game Comic Forum