Gigante or Gigantes may refer to:
In people:
- Evelyn Gigantes (born 1942), Canadian politician and journalist
- Giacinto Gigante (1806–1876), Italian painter
- Louis Gigante, retired Catholic priest and a brother of mobsters Mario and Vincent
- Mario Gigante (born 1923), Caporegime in the Genovese Crime Family
- Vincent Gigante (1928–2005), Boss of the Genovese Crime Family
- El Gigante, or Jorge Gonzáles, former basketball player and professional wrestler
In media:
- Gigante (film), a 2009 Uruguayan film
- Sábado Gigante ("Giant Saturday"), a Spanish American TV program
Other:
- Gigante, Huila, Colombia
- Gigantes, a race of giants in Greek mythology
- Supermercados Gigante, a Mexican supermarket chain