GLC may refer to:
- GLC (rapper), an American rapper signed to Kanye West's G.O.O.D. Music record label
- "GLC: The Carnage Continues...", an episode of The Comic Strip Presents...
- Mazda Familia, also known as the Mazda GLC (Great Little Car), a car sold in North America 1977–1985
- Gas-liquid chromatography, a type of chromatography
- Geographic Locator Codes
- George Costanza, a fictional character on the television series Seinfeld
- Glasgow Central railway station, a railway station in Glasgow, Scotland
- Global Land Coalition
- International Linear Collider, or Global Linear Collider
- Glucose (Glc)
- God's Learning Channel
- Goldie Lookin Chain, Welsh rappers
- Good Luck Charlie, a 2010 Disney Channel family show
- Government-linked company (or corporation)
- Government Law College, Mumbai
- Great Lakes Central Railroad
- Great Lakes Commission
- Greater London Council
- Green Lake Crew, a rowing club based in Seattle, Washington
- Green Lantern Corps, an interstellar police force from the DC Comics universe
- Greater London Chapter Tau Gamma Phi, an existing chapter of the Triskelions Grand Fraternity founded in London, United Kingdom on August 30, 2008 which is embodied by its chapter policies in accordance with the Tenets and Codes of Conduct of the Tau Gamma Phi, Triskelions Grand Fraternity/Sorority
- Grand Lux Cafe, a restaurant
- glc, a screen capture tool for Linux