Gruffudd ( or ) is a Welsh name that may refer to the following people:
- Gruffudd ab Adda (fl. mid 14th century) was a Welsh language poet and musician
- Gruffudd ab Owain Glyndŵr (c.1375-c.1412) led a major revolt in Wales
- Gruffudd ab yr Ynad Coch (1277–1282), Welsh court poet
- Gruffudd ap Cynan ab Owain Gwynedd, the grandson of the king of Gwynedd
- Gruffudd Gryg (1340–1380), Welsh poet from Anglesey, North Wales
- Gruffudd Hiraethog (died 1564), Welsh language poet
- Gruffudd Llwyd (1380–1410), Welsh language poet
- Ioan Gruffudd (born 1973), Welsh actor
- Rhodri ap Gruffudd (1230–1315), the third or fourth son of Gruffydd ap Llywelyn Fawr
- Sir Gruffudd Vychan, (born 1395), Lord of Burgedin, Treflydan, Garth and Gearfawr, Wales
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