Surname
- Athol Guy (born 1940), Australian musician
- Barry Guy (born 1947), British composer
- Billy Guy (1936–2002), American singer
- Brent Guy (born 1960), American football coach
- Buddy Guy (born 1936), American guitarist
- Constantin Guys (1802–1892), French journalist
- Edna Guy (1907–1982), American dancer
- Étienne Guy (1774–1820), Canadian surveyor and politician
- Fabrice Guy (born 1968), French skier
- Fritz Guy (born 1930), American theologian
- Greg Guy, American basketball player
- Henry Lewis Guy (1887–1956), British mechanical engineer
- Jasmine Guy (born 1962), American actress
- John Guy (governor) (died 1629), English merchant and Governor of Newfoundland
- John Guy (historian) (born 1949), British historian
- Nathan Guy (born 1970), New Zealand politician
- Phil Guy (1940–2008), American guitarist
- Ray Guy (born 1949), American football player
- Richard Guy (born 1916), British mathematician
- Rosa Guy (born 1925), American writer
- Thomas Guy (1644–1724), British hospital founder
- William Guy (1810–1885), British physician
- William L. Guy (born 1919), American politician
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