GWR is an acronym that can stand for:
- Great Western Railway (or Great Western Railroad), the name of several different railway operators
- The Gloucestershire Warwickshire Railway — a heritage railway that has taken the initials of the former Great Western Railway Company
- Great Whipsnade Railway
- GWR Group, former commercial radio company: owned radio stations, GWR FM (Bristol & Bath) and GWR FM Wiltshire
- Guinness World Records
- The GWR Records label
- Gravitational Wave Radiation
- Geographically Weighted Regression A local multivariate regression function weighted on spatial dependence
- Gateway router