HDF may refer to:
- Hadfield railway station (National Rail station code), in Derbyshire, England
- Heringsdorf Airport, (IATA airport code), near Garz on the island of Usedom, Germany
- Hierarchical Data Format, file formats and libraries for storing numerical data
- High-density fiberboard, an engineered wood product
- Hubble Deep Field, an image of a small region in the constellation Ursa Major
- Human Development Foundation, an organization in Bangkok, Thailand
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