Henry Vane may refer to:
- Sir Henry Vane the Elder (1589–1655), English courtier, father of Henry Vane the Younger
- Sir Henry Vane the Younger (1613–1662), statesman, Puritan, son of Henry Vane the Elder
- Henry Vane, 1st Earl of Darlington PC (c. 1705–1758)
- Henry Vane, 2nd Earl of Darlington (1726–1792)
- Henry Vane, 2nd Duke of Cleveland (1788-1863)
- Henry Francis Cecil Vane (born 1959)
- John Vane, 11th Baron Barnard, full name Henry John Vane