Hiero or Hieron may refer to:
- A holy shrine, temple, or temple precinct in Ancient Greece
- Hieron, a 5th-century BC potter associated with Makron (vase painter)
- Hiero, a dialogue by Xenophon about Hiero I
- Hiero I, tyrant of Syracuse, Italy (478-467 BC)
- Hiero II, tyrant of Syracuse (270-215 BC)
- Hiero., the author abbreviation for botanist Georg Hans Emmo Wolfgang Hieronymus
- Hiero Desteen, protagonist of two post-apocalypse novels by Sterling E. Lanier (Hiero's Journey and The Unforsaken Hiero)
- Hieroglyphics, a hip-hop group
- Jay Hieron (born 1976), an American professional mixed martial arts fighter.
- Any one of a number of Aero-engines built to the designs of Otto Hieronimus in the Austro-Hungarian empire fromthe early 1910s, such as the Hiero E.
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