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- Headend in the Sky, satellite communications facility
- Highway In The Sky, synthetic vision system for pilots
- HITS algorithm, Hypertext Induced Topic Selection for Web-page rating
- Homicide Investigation Tracking System, murder and rape case database
- High-Impulse Thermobaric Weapons (HITs), a type of explosive that relies on oxygen from the surrounding air
- Heidelberg Institute for Theoretical Studies, a private non-profit research institute in Heidelberg, Germany
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