Hopkinson is a surname of English and Welsh origin, and may refer to:
- Alfred Hopkinson, British politician
- Austin Hopkinson, British politician
- Bertram Hopkinson, British engineer
- Bobby Hopkinson, English footballer
- Carl Hopkinson, English cricketer
- Charles Hopkinson, American artist
- Edward Hopkinson, British politician and engineer
- Francis Hopkinson, American writer and signer of the Declaration of Independence
- George Hopkinson, British general
- John Hopkinson, British physicist
- Mark Hopkinson, American convicted murderer
- Nalo Hopkinson, Jamaican writer
- Richard Hopkinson, British artist
- Simon Hopkinson, British chef and cookery writer
- William C. Hopkinson, British intelligence agent