IPSC may refer to:
- Induced pluripotent stem cell, a type of pluripotent stem cell
- International Practical Shooting Confederation, a shooting sport based on the concept of practical shooting
- Institute for the Protection and Security of the Citizen, located in Ispra, Italy, is one of the seven institutes of the Joint Research Centre, a Directorate-General of the European Commission
- Inhibitory postsynaptic current, in neurobiology
- Intel iPSC, any of several high-performance computers manufactured by Intel
- Internet Problem Solving Contest, an online programming competition
- Intellectual Property Scholars Conference, an annual workshop of presentations focused on intellectual property law and cyberlaw