IRB may refer to:
in organizations:
- International Rugby Board, the governing board of rugby union
- Irish Republican Brotherhood, an Irish secret revolutionary society of the 19th and early 20th centuries
- Institutional review board, a committee to monitor research involving humans
- Immigration and Refugee Board of Canada, a Canadian administrative tribunal
- Ruđer Bošković Institute (Croatian: Institut Ruđer Bošković), a Croatian research institute
- IRB Infrastructure, an Indian road infrastructure company
- Instituto de Resseguros do Brasil, a Brazilian company of reinsurance
- Instituto Ricardo Brennand, a museum in Recife, Brazil
in technology:
- Interactive Ruby Shell, a shell for programming in Ruby
- ASEA IRB, an industrial robot
Other:
- Inflatable Rescue Boat
- Ian Rank-Broadley, a British sculptor
- Internal Ratings-Based Approach (Credit Risk), an approach to estimate capital requirements by banks under the Basel II guidelines
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