Alternatives
The only alternative to isotope separation is to manufacture the required isotope in its pure form. This may be done by irradiation of a suitable target, but care is needed in target selection and other factors to ensure that only the required isotope of the element of interest is produced. Isotopes of other elements are not so great a problem as they can be removed by chemical means.
This is particularly relevant in the preparation of high-grade plutonium-239 for use in weapons. It is not practical to separate Pu-239 from Pu-240 or Pu-241. Fissile Pu-239 is produced following neutron capture by uranium-238, but further neutron capture will produce Pu-240 which is less fissile and worse, is a fairly strong neutron emitter, and Pu-241 which decays to Am-241, a strong alpha emitter that poses self-heating and radiotoxicity problems. Therefore, the uranium targets used to produce military plutonium must be irradiated for only a short time, to minimise the production of these unwanted isotopes. Conversely, blending plutonium with Pu-240 renders it less suitable for nuclear weapons.
Read more about this topic: Isotope Separation
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—Ann Oakley (b. 1944)
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—Connie J. Downey (b. 1934)