Issa or ISSA may refer to:
- Issa
- Abdisalam Issa-Salwe, Somali scholar
- Darrell Issa, a Californian Representative
- List of The Belgariad and The Malloreon characters#Issa, a divine character in David Eddings's fantasy series The Belgariad and The Malloreon
- Issa or Isa, the Arabic name for Jesus in Islam
- Issa (clan), a Somali clan that mainly inhabit Djibouti
- Issa, an ancient Greek colony on the Adriatic island of Vis
- Issa, another name for the Catawba tribe of Native Americans
- Issa, Japanese haiku poet - full name Kobayashi Issa
- Issa, the nickname of Luttif Afif, the leader of the Black September terror squad at the 1972 Olympic Games
- Issa-Aimé Nthépé, French sprinter
- Issa Al Murbati, Guantanamo Bay detainee
- Issa al Qaida guest house, Faisalabad
- Issa (Senegalese singer) (born Issa Diop), singer, songwriter, and record producer
- Issa Hassan, Kurdish musician and singer living in France
- Issa Hentona, lead singer of J-pop band Da Pump
- Issa Sesay, a military leader in the Sierra Leone insurgency
- Issa (clothing), London fashion company, participant in Fall 2008 fashion weeks, known for its artistic prints
- Issa (singer), the identity which Canadian musician Jane Siberry took upon changing her name
- Issa (inhabited locality), name of several inhabited localities in Russia
- ISSA
- International Sailing Schools Association, non-profit European International Sailing Schools Association which was founded 1969 in Paris.
- Independent Schools Sports Association, now known as the Sports Association for Adelaide Schools (SAAS)
- Information Systems Security Association
- Instituto Superior de Secretariado y Administracion (ISSA), a center of the University of Navarra that trains elite management assistants
- Integrated System for Survey Analysis, a joint developer of CSPro
- International Social Security Association, headquartered in Geneva, Switzerland
- International Society for Spelæological Art
- International Society for the Study of Argumentation, academic organisation for those interested in Argumentation theory
- International Sports Sciences Association, an organisation of fitness experts which certifies personal fitness trainers from around the world.
- International Strategic Studies Association
- Interscholastic Sailing Association
- International Sanitary Supply Association
- International Step by Step Association A membership organization that connects professionals and organizations working in the field of early childhood development and education (http://www.issa.nl)
- Irish Seed Savers Association
- Intersex South Africa
- Israel–South Africa Agreement
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