The jackalope is a mythical animal of North American folklore (a so-called "fearsome critter") described as a jackrabbit with antelope horns or deer antlers and sometimes a pheasant's tail (and often hind legs). The word "jackalope" is a portmanteau of "jackrabbit" and "antalope", an archaic spelling of "antelope". It is also known as Lepus temperamentalus.
It is possible that the tales of jackalopes were inspired by sightings of rabbits infected with the Shope papilloma virus, which causes the growth of horn- and antler-like tumors in various places on the rabbit's head and body. This can occur in cottontail rabbits under natural conditions and in domestic rabbits under experimental conditions. Systemic regression of warts occurs in a variable proportion of rabbits as a consequence of a specific cell-mediated immune response. Persistent warts may progress into invasive carcinomas. Progression into carcinomas is observed in approximately 25% of cottontail rabbits and in up to 75% of domestic rabbits with persistent warts. However, the concept of an animal hybrid occurs in many cultures, for example as the griffin and the chimera. Indeed, the term chimera has become the categorical term for such composites within the English language.
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