Jacopo may refer to:
- Jacopo Bassano (c1510–1592), Italian painter
- Jacopo da Bologna (fl 1340–1360), Italian composer
- Jacopo Comin (1518–1594), Italian painter otherwise known as Tintoretto
- Jacopo Carucci (1494–1557), Italian painter otherwise known as Pontormo
- Jacopo Corsi (1561–1602), Italian composer
- Jacopo da Leona (died 1277), Italian poet
- Jacopo Peri (1561–1633), Italian composer
- Jacopo Riccati, Italian mathematician
- Jacopo, a key character in the 2002 film version of The Count of Monte Cristo (and a minor character in the book).
- Jacopo Peterman, character portrayed by John O'Hurley in the sitcom Seinfeld
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