Khama may refer to:
- Seretse Khama
- Tshekedi Khama (1905 - 1959), regent of the Bamangwato tribe in 1923 after the death of Sekgoma II
- Ian Khama
- Sir Seretse Khama International Airport in Botswana
- Khama III
- Ruth Williams Khama
See also Karma
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