Knob may refer to:
- A rounded handle that one pulls or twists:
- Doorknob, a round handle one turns to open any door
- Control knob, controls a device
- Brodie knob on the steering wheel
- A prominent rounded hill or mountain, particularly in the Appalachians and the Ozarks
- Another word for tow ball or hitch ball
- Protrusions on the surface of erythrocytes associated with Maurer's clefts in malaria
- In slang, the male genitalia.
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