KSC can mean:
- Karlsruher SC, a German football team
- Keene State College, a US college that is part of the University System of New Hampshire
- Keepers of The Sacred Chao
- Kelsey-Seybold Clinic, a Houston-based, NASA-affiliated, multi-specialty healthcare system
- Kennedy Space Center, a NASA space vehicle launch facility
- Knights of the Southern Cross, an Australian order of Catholic men
- Communist Party of Czechoslovakia (Komunistická strana Československa)
- Košice International Airport, IATA airport code
- Kofu Shima Corporation, a Japanese manufacturer of airsoft guns
- Kuwaiti joint stock company, a type of enterprise under Kuwaiti law